Utility of Galleria mellonella larvae for evaluating nanoparticle toxicology

The use of nanoparticles in consumer products is currently on the rise, so it important to have reliable methods predict any associated toxicity effects. Traditional vitro assays fail mimic true physiological responses living organisms against whereas murine vivo models are costly and ethically controversial. For these reasons, this study aimed evaluate efficacy Galleria mellonella as an alternative, non-rodent model for examining nanoparticle toxicity. Silver, selenium, functionalized gold were synthesized, their was assessed G. larvae. degree acute effects caused by each type NP efficiently detected array indicators within larvae: LD50 calculation, hemocyte proliferation, distribution, behavioral changes, histological alterations. larvae proposed a nanotoxicological that can be used bridge between order obtain better predictions